Search results for " ovary"

showing 10 items of 206 documents

Semaglutide reduces fat accumulation in the tongue: A randomized single-blind, pilot study

2021

Abstract Aim We evaluated the effect of the latest GLP-1 RA semaglutide on tongue fat storage in obese women. Design. We conducted a randomized single-blind, pilot study. Methods Twenty-five obese women with polycystic ovary syndrome (PCOS) (33.7 ± 5.3 years, body mass index (BMI) 36.1 ± 3.9 kg/m2, mean ± SD) were randomized to semaglutide 1.0 mg or placebo for 16 weeks. We quantified tongue volume and its fat tissue and fat proportion by magnetic resonance imaging. Results Tongue fat tissue and fat proportion significantly reduced after semaglutide vs placebo (-1.94 ± 5.51 vs. + 3.12 ± 4.87 cm3, p = 0.022, and −0.02 ± 0.07 vs. 0.04 ± 0.06, p = 0.010, respectively). Correlation analysis rev…

Adultmedicine.medical_specialtyWaistEndocrinology Diabetes and MetabolismGlucagon-Like PeptidesAdipose tissuePilot ProjectsPlaceboGastroenterologyEndocrinologyDouble-Blind MethodTongueTongueInternal medicineInternal MedicinemedicineHumansSingle-Blind MethodObesityGlucagon like peptide-1 receptor Obesity PCOS Semaglutide Tongue fat Adult Double-Blind Method Female Glucagon-Like Peptides Humans Obesity Pilot Projects Single-Blind Method Adiposity TongueAdipositybusiness.industrySemaglutideGeneral Medicinemedicine.diseaseObesityPolycystic ovarymedicine.anatomical_structureFemalebusinessBody mass index
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Low estradiol-to-testosterone ratio is associated with oligo-anovulatory cycles and atherogenic lipidic pattern in women with polycystic ovary syndro…

2010

The estradiol-to-testosterone (E2/T) ratio has been investigated in different diseases but few in vivo data are available with regard to its role in women with ovary syndrome (PCOS). The aim of this study was to evaluate the role of the E2/T ratio in the ovulatory function and metabolic pattern in such women.We retrospectively evaluated hyperandrogenemia, clinical hyperandrogenism, ovarian morphology, hypothalamo-hypophyseal axis and metabolic syndrome parameters in a cohort of 202 consecutive women affected by PCOS. An oral glucose tolerance test measured areas under the curve for insulin (AUC(2hIRI)), for glucose (AUC(2hglucose)), and the HOMA-IR and Matsuda index of insulin resistance we…

Adultmedicine.medical_specialtyAdolescentEndocrinology Diabetes and Metabolismmedia_common.quotation_subjectOvarySettore MED/13 - EndocrinologiaCohort StudiesYoung AdultEndocrinologyInsulin resistanceRisk FactorsInternal medicineFollicular phasePCOSmedicineHumansTestosteroneSicilyOvulationProgesteroneMenstrual cycleRetrospective Studiesmedia_commonEstradiolbusiness.industryOvaryHyperandrogenismObstetrics and GynecologyAtherosclerosismedicine.diseasePolycystic ovaryCholesterolEndocrinologymedicine.anatomical_structureFollicular PhaseFemaleMetabolic syndromeHyperandrogenismbusinessAlgorithmsAnovulationPolycystic Ovary SyndromeGynecological Endocrinology
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Uterine effects of metformin administration in anovulatory women with polycystic ovary sindrome

2006

Background Metformin has been shown to improve fertility in anovulatory patients with polycystic ovary syndrome (PCOS), inducing not only a high ovulation and pregnancy rate but also reducing the incidence of miscarriages. The aim of the present study was to evaluate the uterine effects of metformin in patients with PCOS who ovulated under metformin. Methods Thirty-seven non-obese primary infertile anovulatory patients with PCOS and another 30 age- and body mass index-matched healthy women (control group) were studied. PCOS patients were treated with metformin (850 mg twice daily) for 6 months, whereas the control group did not receive any treatment. In these PCOS patients who ovulated whil…

Adultmedicine.medical_specialtyendocrine system diseasesPhysiologymedia_common.quotation_subjectUterusEndometriumFertility AgentsAnovulationEndometriumanovulation; endometrium; metforminMenstruation-Inducing AgentUltrasoundmedicinePCOSHumansOvulationFertility Agentmedia_commonGynecologyMenstruation-Inducing Agentsbusiness.industryRehabilitationUterusanovulation endometrium metformin PCOS ultrasoundnutritional and metabolic diseasesObstetrics and Gynecologymedicine.diseasePolycystic ovaryfemale genital diseases and pregnancy complicationsMetforminMetforminPregnancy ratemedicine.anatomical_structureUteruReproductive MedicineIn uteroRegional Blood FlowFemalebusinessmedicine.drugAnovulationHumanPolycystic Ovary SyndromeDevelopmental Biology
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The cAMP Pathway Sensitizes VR1 Expressed in Oocytes from <i>Xenopus laevis</i> and in CHO Cells

2003

The vanilloid receptor 1 (VR1) is a heat-activated cation channel which also responds to capsaicin and other chemical stimuli. Protein kinase C has a stimulatory effect on VR1 activity, either alone or after activation with capsaicin. The influence of the cAMP-signaling pathway on the effects of capsaicin is controversial. To clarify this, the actions of capsaicin and the modulatory effects of forskolin, pCPT-cAMP, and isobutylmethylxanthine were studied in <i>Xenopus laevis</i> oocytes expressing rat VR1 and in CHO cells expressing human VR1. Capsaicin activated the VR1 channel and increased the intracellular calcium concentration. The effects of capsaicin were enhanced by fors…

Pharmacologymedicine.medical_specialtyForskolinbiologyChinese hamster ovary cellTRPV1XenopusGeneral Medicinebiology.organism_classificationCalcium in biologyCell biologychemistry.chemical_compoundEndocrinologychemistryCapsaicinInternal medicinemedicinecAMP-dependent pathwaylipids (amino acids peptides and proteins)Protein kinase CPharmacology
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A 20-year follow-up of young women with polycystic ovary syndrome.

2012

OBJECTIVE: To determine whether hormonal, metabolic, and anthropomorphic parameters change over 20 years in women with polycystic ovary syndrome (PCOS). METHODS: One hundred ninety-three women with PCOS, aged 20–25 years, were diagnosed according to Rotterdam criteria, divided into four phenotypes (A–D), and followed at 5-year intervals for 20 years. Androgens, gonadotropins, insulin, glucose, body mass index, waist circumference, and ovarian volume were measured. RESULTS: At diagnosis, 57% had classic features (phenotype A), 9% had classic features without ovarian findings (phenotype B), 26% had the ovulatory phenotype (C), and 7% were nonhyperandrogenic (D). After 10 years, androgens decr…

Adultendocrine system diseasesPhysiologySettore MED/13 - EndocrinologiaBody Mass IndexYoung AdultInsulin resistanceOvarian functionmedicineHumansInsulinTestosteroneYoung adultInsulin bloodbusiness.industryOvaryFollow up studiesObstetrics and GynecologyDehydroepiandrosteroneOrgan SizeLuteinizing HormoneMiddle Agedmedicine.diseasePolycystic ovaryfemale genital diseases and pregnancy complicationsPolycystic Ovary Syndrome Ovarian function Ovarian aging Androgens Insulin resistance waist circumferencePhenotypeFemaleFollicle Stimulating HormoneInsulin ResistanceWaist CircumferencebusinessBody mass indexHormoneAnovulationFollow-Up StudiesPolycystic Ovary SyndromeObstetrics and gynecology
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Lipidomics reveals altered biosynthetic pathways of glycerophospholipids and cell signaling as biomarkers of the polycystic ovary syndrome

2017

// Mariona Jove 1, * , Irene Pradas 1, * , Alba Naudi 1, * , Susana Rovira-Llopis 2 , Celia Banuls 2 , Milagros Rocha 2 , Manuel Portero-Otin 1 , Antonio Hernandez-Mijares 2, 3, 4, # , Victor M. Victor 2, 5, # and Reinald Pamplona 1, # 1 Department of Experimental Medicine, Lleida University-Institute for Research in Biomedicine of Lleida (UdL-IRBLleida), 25198 Lleida, Spain 2 Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO), Service of Endocrinology, University Hospital Dr. Peset, 46017 Valencia, Spain 3 Fundacion Investigacion Hospital Clinico Universitario/INCLIVA, Valencia University, 46010 Valencia, Spain 4 Department of Medicine, …

0301 basic medicineOncologyCell signaling moleculesmedicine.medical_specialtyCell signalingGlycerophospholipidsDiseaseGlycerophospholipidsFree fatty acidsValencian community03 medical and health sciences0302 clinical medicineInternal medicineLipidomicsmedicinelipid de novo biosynthesisglycerophospholipids030219 obstetrics & reproductive medicinebusiness.industryfree fatty acidsLipidomeUniversity hospitalPolycystic ovary030104 developmental biologyOncologyLipidomicscell signaling moleculeslipidomicsbusinessResearch PaperOncotarget
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Difference in body weight between American and Italian women with polycystic ovary syndrome: influence of the diet.

2003

BACKGROUND The study aim was to determine differences in body mass in two populations of women (USA and Italy) with polycystic ovary syndrome (PCOS), and to assess the effect of diet on body mass and cardiovascular risk factors. METHODS Pools of women with PCOS from the USA (n = 343) and Italy (n = 301), seen between 1993 and 2001, were available for assessment. From these populations, 20 women who were seen consecutively in 2001 at each site had detailed analyses of diet and cardiovascular risk factors. RESULTS In the entire group, American women had a significantly higher body mass compared with Italian women (P < 0.01). Also, the 20 women consecutively evaluated in the USA had a signific…

Adultmedicine.medical_specialtySaturated fatBody Mass Indexchemistry.chemical_compoundInsulin resistanceRisk FactorsInternal medicinemedicineHyperinsulinemiaHumansRisk factorTriglyceridesbusiness.industryCholesterolRehabilitationBody WeightCholesterol HDLFatty AcidsObstetrics and Gynecologymedicine.diseaseObesityPolycystic ovaryDietary FatsUnited StatesDietEndocrinologyReproductive MedicinechemistryItalyCardiovascular DiseasesFemaleInsulin ResistancebusinessBody mass indexPolycystic Ovary SyndromeHuman reproduction (Oxford, England)
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The importance of diagnosing the Polycystic Ovary Syndrome

2000

The polycystic ovary syndrome (PCOS) is an extremely common disorder that occurs in 4% to 7% of women of reproductive age. Although PCOS is known to be associated with reproductive morbidity and increased risk for endometrial cancer, diagnosis is especially important because PCOS is now thought to increase metabolic and cardiovascular risks. These risks are strongly linked to insulin resistance and are compounded by the common occurrence of obesity, although insulin resistance and its associated risks are also present in nonobese women with PCOS. Women with PCOS are at increased risk for impaired glucose tolerance, type 2 diabetes mellitus, and hypertension. Cardiovascular disease is believ…

medicine.medical_specialtyendocrine system diseasesPhysiologyType 2 diabetesImpaired glucose toleranceInsulin resistanceDiabetes mellitusInternal medicineGlucose IntoleranceInternal MedicinemedicineHumansRisk factorbusiness.industryFibrinolysisnutritional and metabolic diseasesType 2 Diabetes MellitusGeneral Medicinemedicine.diseaseObesityPolycystic ovaryLipidsfemale genital diseases and pregnancy complicationsEndocrinologyCardiovascular DiseasesFemalepolycystic ovary syndrome cardiovascular risk insuline resistanceInsulin ResistancebusinessHyperandrogenismAnovulationPolycystic Ovary Syndrome
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Diagnosis, phenotype, and prevalence of polycystic ovary syndrome.

2006

New diagnostic criteria for polycystic ovary syndrome (PCOS) suggested three main phenotypes: classic (hyperandrogenism and anovulation), ovulatory, and normoandrogenic. However, it is unclear whether the normoandrogenic phenotype actually represents PCOS. Overall, 6% to 8% of reproductive-aged women suffer from PCOS, making this disorder one of the most common endocrine abnormalities.

medicine.medical_specialtyHirsutismendocrine system diseasesPolycystic ovary syndrome anovulation hyperandrogenismThree main phenotypesBiologyAnovulationDiagnosis DifferentialEpidemiologymedicinePrevalenceEndocrine systemHumansCystGynecologyHyperandrogenismnutritional and metabolic diseasesObstetrics and Gynecologymedicine.diseasePolycystic ovaryPhenotypefemale genital diseases and pregnancy complicationsPhenotypeReproductive MedicineFemaleHyperandrogenismAnovulationPolycystic Ovary SyndromeFertility and sterility
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Metabolically healthy polycystic ovary syndrome (MH-PCOS) and metabolically unhealthy polycystic ovary syndrome (MU-PCOS): a comparative analysis of …

2013

Study question Is it possible to distinguish metabolically healthy polycystic ovary syndrome (MH-PCOS) from metabolically unhealthy PCOS (MU-PCOS) by simple diagnostic tools such as body mass index (BMI), waist/hip ratio (WHR), at-risk category suggested by Androgen Excess Society (AES) and visceral adiposity index (VAI)? Summary answer VAI could be an easy and useful tool in clinical practice and in population studies for assessment of MU-PCOS. What is known already VAI is a good indicator of insulin sensitivity and cardiometabolic risk in oligo-ovulatory women with PCOS. Study design, size, duration We conducted a cross-sectional study of 232 women with PCOS in a university hospital setti…

Adultmedicine.medical_specialtyWaistAdolescentPopulationSettore MED/13 - EndocrinologiaDiagnosis DifferentialInsulin resistanceRisk FactorsInternal medicinemedicinePCOSHumanseducationAdiposityeducation.field_of_studybusiness.industryRehabilitationnutritional and metabolic diseasesObstetrics and GynecologyOdds ratioGlucose Tolerance Testmedicine.diseasePolycystic ovaryConfidence intervalCross-Sectional StudiesPhenotypeReproductive MedicineFemaleMetabolic syndromeInsulin ResistancebusinessEnergy MetabolismBody mass indexPolycystic Ovary SyndromeHuman reproduction (Oxford, England)
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